Mitochondria in response to nutrients and nutrient-sensitive pathways.

Abstract Mitochondria are abundant cellular organelles, and are required for the generation of energy through oxidative catabolism. Equally important, mitochondria also provide substrates for de novo synthesis of fatty acids and multiple amino acids. Mitochondrial functions must therefore be tightly linked to cellular nutrient availability. This review focuses on the current knowledge of how nutrients affect mitochondria. In particular, we describe how the transcriptional profile of the nucleus is altered to mediate this control, and the transcription factors that are involved. In addition, we summarize recent progress in our understanding of how transcription-independent mechanisms, most notably through the cellular energy sensor mTOR, are used to adapt mitochondrial functions in respect to cellular metabolic needs.