Effects of treatment with a cetylated fatty acid topical cream on static postural stability and plantar pressure distribution in patients with knee osteoarthritis.
2005
The purpose of
the present investigation was to examine the effects of 30 days
of treatment with a topical cream consisting of cetylated fatty
acids on static postural stability and plantar pressures in patients
with osteoarthritis (OA) of one or both knees. Forty patients
diagnosed with knee OA were randomly assigned to 1 of
2 topical treatment groups: (a) cetylated fatty acid (CFA; N =
20; age = 62.7 ± 11.7 years); or (b) placebo (P; N = 20; age =
64.6 ± 10.5 years). Patients were tested on 2 occasions: (a) baseline
(T1), and (b) following a 30-day treatment period consisting
of cream application twice per day (T2). Assessments included
20- and 40-second quiet standing protocols on a force plate to
measure center of pressure (COP) total excursion length, COP
velocity, and rearfoot and forefoot plantar pressure distribution.
In the CFA group, a significant reduction in the COP excursion
length and velocity were observed at T2, whereas no significant
differences were observed in the P group. No significant differences
in mean forefoot, rearfoot, or rearfoot-to-forefoot plantar
pressure ratios were observed in either group at T2. However,
in a subgroup of participants designated to be right- or left-side
dominant, improvements in the right-to-left forefoot plantar
pressure ratios were observed in both groups. These data indicate
that 30 days of treatment with a topical cream consisting
of cetylated fatty acids improves static postural stability in patients
with knee OA presumably due to pain relief during quiet
standing. Such over-the-counter treatment may help improve
the exercise trainability of people with OA.
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