Risk factors of transfusion related acute lung injury A systematic review

Summery Objective: The aim of this study was to determine the risk factors of Transfusion-Related Acute Lung Injury (TRALI). Methods: Pubmed was searched; original studies, with a control group, about individual risk factors of TRALI in adults, were included. Results: Seven studies met the selection criteria, and were consequently included. Ultimately 24 risk factors were assessed, 2 of which (amount of plasma and amount of platelet units transfused) were unanimously proven to be significant. Leukoreduced PRBCs, RBCs from female donors, age of RBC units, anti HNA, male sex, smoking, diabetes, CABG and aspiration were proven to not influence the risk of TRALI. All other risk factors remained controversial in these studies. After correction for multiple testing, only one of the risk factors (amount of platelet units transfused) remained significant in one study. Conclusions: We can conclude that many of the risk factors for TRALI remain controversial.