Synthesis, Characterization and Biological evaluation of some newer 5-(6-chloro/fluoro/nitro-2- (p-chloro/ fluoro/ methyl phenyl)-quinolin-4-yl)-1,3,4- oxadiazole-2-thiols

Recent study shows that quinolines represent one of the most active classes of compounds possesses wide spectrum biodynamic activities and use as potent therapeutic agents. In present research work, 5-[6-chloro/fluoro/nitro-2-(p-chloro/fluoro/methyl phenyl)-quinolin-4-yl]-1,3,4oxadiazole-2-thiols have been synthesized by condensation of substituted quinoline-4carbohydrazides and mixture of carbon disulphide and potassium hydroxide. All of these compounds were screened for their in vitroanti microbial assay against gram (+ve), gram (-ve) bacteria and fungi activity compared with standard drugs viz., Ampicilin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Griseofulvin and Nystatin at different concentrations.