Aspirin-esomeprazole compound enteric coated pellet preparation and preparation method

The invention relates to an aspirin-esomeprazole compound enteric coated pellet preparation and a preparation method. The preparation is composed of active pharmaceutical ingredients aspirin and esomeprazole and other pharmaceutically acceptable auxiliary materials. The aspirin and the esomeprazole are in a mass ratio of 3-6:1. The compound enteric coated pellet has two forms. For one form of enteric coated pellet, aspirin pellet is adopted as a drug-containing pellet core, which is externally coated by an isolation layer I, an ensomeprazole magnesium drug layer, an isolation layer II, and an enteric coating layer; and for the other form of enteric coated pellet, an aspirin enteric coated pellet and an esomeprazole enteric coated pellet are prepared respectively, and they are mixed to obtain the compound enteric coated pellet. According to the invention, the drugs are released in the intestinal tract, thus avoiding destruction of the drugs in an acidic environment of the stomach; the compound preparation can resist the side effects of aspirin on gastrointestinal irritation so as to facilitate long-term medication of aspirin and bring the platelet aggregation inhibition effect of aspirin into play; and by adopting pellet form release drugs, the bioavailability is high, the blood concentration fluctuation is small, and the side effects are smaller.