The effect of Dioscorea opposita polysaccharide in the treatment of rats with gastric ulcer and its influence on the level of EGF in gastric ulcer tissues

Objective To observe the therapeutic effect of Dioscorea opposita polysaccharide on gastric ulcer in rats,and to investigate the effects of Dioscorea opposita polysaccharide on level of epidermal growth factor （ EGF） in stomach tissues .Methods 50 rats were randomly divided into five groups [ A group （ normal control group ） , B group（model group）,C group（Dioscorea opposita polysaccharide group ）,D group（teprenone group）].The healing condition of gastric ulcer and EGF level were observed and compared .Results （1）The ulcer index of C group was obviously reduced compared with B group （P〈0.01）.（2）Between C group and A group,the significant difference existed in the level of EGF（P〈0.05）,while the difference was not statistically significant between C group and D group（P〉0.05）.Conclusion Dioscorea opposita polysaccharide has protective effects for gastric mucosa .The mechanism of protection may be related to promote synthesis of EGF . Key words: Ipomoea batatas ;  Polysaccharides ;  Stomach ulcer;  Epidermal growth factor;  Rats