A study on association of serum osteocalcin and adiponectin with diabetic markers in genetically high risk for type 2 diabetes population.

Aims: In view of significant role of osteocalcin and adiponectin in the onset of insulin resistance and diabetes in rat model and cell line studies we aimed to study the influence of family history for diabetes on osteocalcin and adiponectin levels and their role in initiating the changes in diabetic markers in healthy adult springs of diabetic parents, thus a hypothesis can be drawn on their role in developing diabetes in high risk population. Methodology: Age between 18 to 22 years was selected and divided into three groups. Group I: control group consists (n=81) with no family history of diabetes. Group II: (n=147) with one of their parents with history of type 2 diabetes. Group III: (n=47) with both parents having history of type 2 diabetes. In all the groups we estimated fasting plasma glucose, lipid profile, insulin and adiponectin and osteocalcin. Results: We observed significant lower levels of adiponectin 8.7 ± 1µg/ml in group-III