Potassium signalling of metabolic interactions between neurons and glial cells

Abstract Active neurons release potassium into the intercellular spaces. Adjacent astrocytes and other non-myelin forming glial cells respond by depolarization and temporary accumulation of the released potassium. The increased intracellular potassium signals metabolic changes within the glial cell cytoplasm which are beneficial to the neurons. When blood glucose is adequate, the signal promotes glycogen synthesis and turnover within the glial cells. The glycogen stores may ensure adequate energy supplies to the neurons if local blood glucose levels become inadequate.