Figure 3: CM-Specific SMAD4 Deletion Induces Cardiac Remodeling

Morphometric studies were performed at the end of 8 weeks after TAM treatment. (A) Heart weight (HW) to tibia length (TL). (B) Lung weight (LW) to TL. (C) Quantification of cardiomyocyte cross-sectional area (CSA). ***p = 0.0002 versus MCM group. (D) Masson’s trichome staining. Representative trichome-stained LV regions. (E) Quantification of LV fibrosis. *p = 0.0165 versus MCM group. Scale bar = 30 μm. Abbreviations as in Figures 1 and 2.