Antipyretic Activities of Methanol Extract of the Ganoderma sinense J.D. Zhao, L.W. Hsu & X.Q. Zhang on Albino Rats-An Experimental Study

Aim: Antipyretic effect of the methanol extract of Ganoderma sinense against Brewer’s yeast induced pyrexia model in albino rats of both sexes was investigated. Methods: Pyrexia was induced by subcutaneously injecting 20% w/v Brewer's yeast suspension (20ml/kg) in the back below the nape of the neck of animals. Twenty four hours after the injection, the rectal temperature of each rat was measured. The temperature was measured at 30, 60, 90 and 120 min. after drug administration. Paracetamol (150mg/kg p. o.) was used as standard drug. The group received methanol extract 300mg/kg showed significant decrease in rectal temperature from 39.42± 0.24 to 35.50± 0.34 as compared with the group received standard drug. All experimental values are given as means ± standard deviation (SD). Statistical significance was determined by one-way variance analysis (ANOVA). Differences at P < 0.05 were considered to be significant. Results: The statistically processed results support the conclusion, that the methanol extract of Ganoderma sinense (300mg/kg) possesses dose dependent significant antipyretic activity. Conclusion: From the study it was concluded that Wild Mushroom of Ganoderma sinense possess significant antipyretic activity.