Androgenic therapy in malignant disease of the female genitalia Preliminary report

Abstract A series of patients with previously treated but progressively advancing malignancies of the female genitalia have been given testosterone propionate in arbitrary dosage of 140 to 150 mg, weekly. Cases include carcinomas of the breast, ovary, Fallopian tube, uterine corpus and cervix. A preliminary report of five cases in detail including carcinomas of the uterine corpus and cervix is presented. These patients have been receiving treatment for ten months. A theoretical consideration of the basis for this clinical investigation is given and our observations noted. Symptomatically, these patients have been definitely improved. Feeling of well-being, improved morale, control of menopausal symptoms, and increased libido have all been regularly observed and these observations alone seemed to us to warrant the administration of male hormone in this unfortunate group of patients. To date, there is nothing to indicate any regression or even retardation of the malignant process.