Temporary perfusion substitution of liver and spleen functions in patients with peritonitis

Thirty-one patients with generalized purulent peritonitis of various etiology were examined; a new perfusion method with the use of isolated live hepatocytes and xenospleen fragments was applied in the intensive therapy complex in the early period after a cavitary operation in 16 patients. It is shown that the suggested method has significant advantages over the traditional methods in that it causes effective detoxification, improves microcirculation, and reduces the indicators of the cytologic syndrome. Application of the hybrid system of detoxification in patients with peritonitis made it possible to reduce the lethality among the most serious patients with infectious-toxic shock and polyorganic insufficiency.