Acanthosis Nigricans in the Knuckles of Infants: A Novel Clinical Marker of High Metabolic Risk

Introduction Acanthosis nigricans (AN) is an early clinical sign of insulin resistance (IR) primarily in adults. The prevalence and association of AN and IR in infants, however, remains uncertain. We aimed to describe the prevalence of AN and its association with IR in a group of Latin-American infants.