Abstract P197: The Relationship Between Thyroid-Stimulating Hormone Levels and Lipoprotein Subfractions in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Background and purpose: Although the relation between thyroid disorders and heart diseases had been described since decades ago, the association of thyroid-stimulating hormone (TSH) and lipoproteins is not very well elucidated. Hypothesis: to verify if there are associations with TSH levels, lipid and lipoprotein subfractions in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: We evaluated at the ELSA-Brasil baseline (2008-2010) 3,742 middle-aged participants (1,960 women and 1,782 women) without previous cardiovascular disease and people who were taking neither drugs that can interfere with thyroid function nor lipid-lowering agents. All of them had their levels of total-cholesterol and its sub-fractions (LDL, VLDL and HDL subclasses); triglycerides and triglyceride-rich lipoprotein cholesterol [TRL-C (VLDL1+2-C VLDL3-C + IDL-C)] determined by ultracentrifugation (Vertical Auto Profile, Atherotech). We also calculated T-Chol/HDL-C and triglycerides/HDL-C ratios. The application mu...