[Effects of tongxinluo capsule on cardiac ventricle remodeling after myocardial infarction: a multicentre clinical research].
2008
Objective To investigate the effects of tongxiuluo (TXL) capsule on cardiac ventricle remodeling after acute myocardial infarction (AMI). Methods Seventy AMI patients were randomly divided into 2 equal groups: conventional therapy group treated with conventional Western therapy and TXL treatment group treated with TXL capsule for 6 weeks in addition to the conventional treatment. Cardiac color ultrasound was conducted before and 6 weeks after the treatment to examine the changes of ventricular structure, mass and function. Radioimmunoassay was used to detect the levels of angiotensin Ⅱ ( Ang Ⅱ) and endothelin-1 (ET-1). Results Six weeks later, the left ventricular posterior wall thickness of end- diastolic (LVPWTD), left ventrieular end-systolic dimension( LVESD), and left atrium dimension (LAD) of the TXL group were 0.93 cm ± 0. 09 cm, 3.71 cm ± 0.19 cm, and 3.21 cm±0.29 cm respectively, all lower than those before treatment (0.93 cm±0.09 cm, 3.71 cm ±0. 19 cm, and 3.21 cm±0.29 cm respectively)and those of the conventional treatment group (0.95 cm±0.08 cm, 3.62 cm±0.46 cm, and 3.82 cm±0.30 era) ( all P 0.05 ), the ejection-fraction (EF) improvement rate of the TXL group was 63%±7%, significantly higher than that before treatment (52% ± 6% ) and that of the conventional treatment group (59% ± 8% , both P 0.05 ) . Conclusion TXL capsule in addition to conventional therapy has a positive effect on the prognosis of AMI via reversing the ventricular remodeling, and improving cardiac function.
Key words:
Myocardial infarcton; Ventricular remodeling; Tongxinluo capsule
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