NIMG-21EVALUATING THE RESPONSE TO BEVACIZUMAB IN HIGH GRADE GLIOMAS: THE IMPORTANCE OF CLINICAL ASSESSMENT

BACKGROUND: The assessment of Bevacizumab efficacy in high-grade gliomas (HGG) depends on the response criteria used, with discrepancies between T1 Gadolinium-enhanced sequences, T2 sequences and neurological outcome. The aim was to compare McDonald's, RANO and RECIST 1.1 criteria to the clinical outcome in a consecutive series of HGG patients. METHODS: HGG patients treated at the Montpellier Cancer Institute were retrospectively selected. Patients with a Performance Status (PS) 20% of the product of perpendicular diameters. CONCLUSIONS: The high correlation between McDonald's and RANO criteria demonstrates the importance of accurately assessing changes in steroids and neurological state, as well as imaging response, in order to avoid concluding to a false efficacy on imaging only, when using the McDonald's criteria. These results raise the question of the value of the FLAIR assessment when McDonald's criteria are rigorously applied.