Phase I pharmacokinetic study of chronomodulated dose-intensified combination of capecitabine and oxaliplatin (XELOX) in metastatic colorectal cancer

Mohamad Farid,Balram Chowbay,Xiangai Chen,Sze Huey Tan,Saminathan Ramasamy,Wen Hsin Koo,Han Chong Toh,Su Pin Choo,Simon Yew-Kuang Ong

Phase I pharmacokinetic study of chronomodulated dose-intensified combination of capecitabine and oxaliplatin (XELOX) in metastatic colorectal cancer

2012

Mohamad Farid
Balram Chowbay
Xiangai Chen
Sze Huey Tan
Saminathan Ramasamy
Wen Hsin Koo
Han Chong Toh
Su Pin Choo
Simon Yew-Kuang Ong

Purpose To evaluate the maximum tolerated dose (MTD) and pharmacokinetic profile of a chronomodulated, dose-intensified regimen of capecitabine in combination with oxaliplatin (XELOX) in metastatic colorectal cancer (mCRC).

Keywords:

Capecitabine
Regimen
Cancer research
Colorectal cancer
Oncology
Pharmacology
Maximum tolerated dose
Oxaliplatin
Medicine
Internal medicine
Pharmacokinetics
pharmacology toxicology

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