Cyclooxygenase 2-derived prostaglandin E 2 regulates the angiogenic switch

ditionally, they confirmed the role of COX-2 by using the COX-2 selective inhibitor celecoxib. Epidemiological, experimental, and clinical studies have demonstrated that aspirin and other NSAIDs reduce the risk of colorectal cancer (7). Because many other human cancers reportedly have elevated levels of COX-2 and overproduce prostaglandins, intense research efforts are underway to evaluate the role of NSAIDs in both the prevention and possible treatment of a number of human malignancies,