Studies on the Syntheses of N-Heterocyclic Compounds. IV. Hypocholesterolemic 1, 2, 4-Oxadiazole Derivatives. (2)
1973
The derivatives of 3-[4-(1-ethoxycarbonyl-1-methylethoxy) phenyl]-5-(3-pyridyl)-1, 2, 4-oxadiazole (I), which showed considerable hypocholesterolemic activities, were synthesized. Among them, 3-[4-(1-ethoxycarbonyl-1-methylethoxy) phenyl]-5-(2-or 3-chlorophenyl)-1, 2, 4-oxadiazole (13, 14) and their amide derivatives (29, 30) showed nearly equal activity to I. Two alternative synthetic routes of I were developed.
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