Study of thermally induced interaction between hydroxyethylcellulose and carboxymethylcellulose with different excipients

The aim of the present paper was the study of excipient–excipient interactions. It presents the compatibility study between two polymeric compounds used in pharmaceutical technology, namely carboxymethylcellulose and hydroxyethylcellulose, with other commonly used pharmaceutical excipients, such as polyvinylpyrrolidone, sorbitol, magnesium stearate, and talc. The compatibility investigations were carried out under ambient temperature and after decomposition by FTIR spectroscopy studies and later completed by the use of thermal analysis (TG/DTG/HF) data to study the influence of temperature over stability of binary mixtures. Carboxymethylcellulose and hydroxyethylcellulose present thermal-induced interactions with sorbitol and magnesium stearate.