Inactivation of Streptokinase by Bovine Plasmin

Bovine plasma, activated by urokinase or activated spontaneously, inactivates streptokinase (SK). The process is time-consuming, and the kinetics of the process indicate that SK is digested by bovine plasmin. Various plasma protein fractions, such as bovine and human fibrinogen, human plasminogen, and even human albumin, inhibit the inactivation of SK.Human plasmin, activated in the same manner, does not appreciably influence the stability of SK.