Abstract 110: Genetic Analysis Implicates LDL Cholesterol Reduction and Plasminogen Activator-inhibitor 1 Antagonism as Therapeutic Interventions for Venous Thromboembolism

Derek Klarin,Emma Busenkell,Renae Judy,Julie Lynch,Krishna G. Aragam,Mark Chaffin,Mary E. Haas,Themistocles L. Assimes,Jie Huang,Kyung-Min Lee,Qing Shao,Jennifer E. Huffman,Yunfeng Huang,Yan V. Sun,Marijana Vujkovic,Danish Saleheen,Donald R. Miller,Peter D. Reaven,Scott L. DuVall,William E. Boden,Saiju Pyarajan,J. Michael Gaziano,John Concato,Daniel J. Rader,Kelly Cho,Kyong-Mi Chang,Peter W.F. Wilson,Nicholas L. Smith,Christopher J. ODonnell,Philip S. Tsao,Sekar Kathiresan,Pradeep Natarajan,Scott M. Damrauer

Abstract 110: Genetic Analysis Implicates LDL Cholesterol Reduction and Plasminogen Activator-inhibitor 1 Antagonism as Therapeutic Interventions for Venous Thromboembolism

2019

Introduction: Venous thromboembolism (VTE) is a significant heritable cause of cardiovascular-related mortality, yet previously published GWAS have only identified 11 genome-wide significant (P<5x1...

Keywords:

ldl cholesterol
venous thromboembolism
Bioinformatics
Plasminogen activator inhibitor-1
Genome-wide association study
Antagonism
Venous thrombosis
Genetic analysis
Medicine

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