Novel ether derivatives of alkyl piperidines as potential sigma / 5HT2 antipsychotic agents

Abstract A series of novel cinnamyl and propargyl ether derivatives of alkyl piperidines which show high affinity for sigma and 5HT 2 receptors are described. The ligands exhibit high selectivities for these receptors over D 2 as well as good activity in vivo in anti-mescaline scratch assay.