Роль провоспалительных факторов в оценке прогноза больных прогрессирующей стенокардией в сочетании с сахарным диабетом 2 типа

Aims. Our study was aimed to assess the influence of non-specific inflammation and endothelial dysfunction on development of cardiovascular events in patients with type 2 diabetes mellitus (T2DM) and progressive angina pectoris. Materials and methods. 140 patients (63 of them were also diabetic) received follow-up for cardiovascular events during 12 months after an episode of unstable angina pectoris. Upon hospitalization for acute coronary syndrome analyses were performed to assess the degree of systemic inflammation evaluating plasma concentration of proand anti-inflammatory markers (CRP, fibrinogen, IL-6, -8, -10, TNF-ƒ), as well as blood glucose and glycated haemoglobin HbA1c. Results. TNF-ƒ and IL-6 levels were significantly higher in patients with unfavorable prognosis (p