Peripheral blood immune correlates associated with TGF-β inhibition (galunisertib) and stereotactic body radiotherapy (SBRT) in patients with advanced hepatocellular carcinoma (HCC).

Max M. Wattenberg,Kim A. Reiss,Michael Giannone,Nevena Damjanov,Elizabeth Prechtel Dunphy,Lisa DiCicco,Luis Garcia-Marcano,Thomas Benjamin Karasic,Emma E. Furth,A.P. Wojcieszynski,Robert H. Vonderheide,Edgar Ben-Josef,Gregory L. Beatty

Peripheral blood immune correlates associated with TGF-β inhibition (galunisertib) and stereotactic body radiotherapy (SBRT) in patients with advanced hepatocellular carcinoma (HCC).

2020

Max M. Wattenberg
Kim A. Reiss
Michael Giannone
Nevena Damjanov
Elizabeth Prechtel Dunphy
Lisa DiCicco
Luis Garcia-Marcano
Thomas Benjamin Karasic
Emma E. Furth
A.P. Wojcieszynski
Robert H. Vonderheide
Edgar Ben-Josef
Gregory L. Beatty

4575Background: TGF-β is a pleiotropic cytokine with immunosuppressive activity. In mouse models, blockade of TGF-β signaling enhances the activity of radiation and invokes T cell dependent anti-tu...

Keywords:

stereotactic body radiotherapy
Oncology
Galunisertib
Transforming growth factor
Internal medicine
Hepatocellular carcinoma
Pathology
in patient
Medicine
peripheral blood
immune correlates

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