mRNA Trafficking to Synapses and Memory Formation

This chapter reviews evidence for the theory that local translation of mRNAs at synapses plays a critical role in synaptic modifications underlying memory consolidation. We consider mechanisms of neuronal cell biology that underlie mRNA transport into dendrites, localization at synapses, and control of local mRNA translation during synaptic plasticity. The final section reviews studies of the immediate early gene Arc, which provide insights into mechanisms linking local translation and memory consolidation.