Basic theory and methods of dosimetry for use in risk assessment of genotoxic chemicals

The continued work is planned to follow the lines indicated in the initial plan of September 28, 1987 and as sketched in the report for the second year. The work, interdisciplinary in character, will evaluate genetical, cytological, molecular-biological and chemical measurements with respect to relevance and sensitivity (resolving power) in risk estimation. The fact is being considered that human populations exhibit a strong variation in hereditary and acquired sensitivity to carcinogens and that, further, exposure to carcinogens may affect this sensitivity with deviations from linearity of dose-response curves in consequence. Several papers on these subjects are in preparation. We see it as a goal of the project to prepare a comprehensive review of the subject, with efforts to identify lines of research that could fill gaps in the present knowledge.