Amino ester derivatives of alkaloids and medicinal composition of these

2011 
A compound of the general Formula (I) ** Formula ** wherein: R1 is selected from the group consisting of aryl, heteroaryl, aryl (C1-C6) alkyl and heteroaryl (C1-C6) alkyl, optionally substituted by one or plus substituents selected from the group consisting of halogen, OH, oxo, SH, NH2, NO2, CN, CON (R5) 2, NHCOR5, COR5, CO2R5, (C1-C6) alkylsulfanyl, (C1-C6) alkylsulfinyl, (C1-C6) alkylsulfonyl, (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) alkoxy and (C1-C6) haloalkoxy; R2 is H or is selected from the group consisting of (C1-C6) alkyl, (C3-C8) cycloalkyl, and aryl (C1-C6) alkyl, optionally substituted by one or more substituents selected from the group consisting of halogen atoms, OH, oxo, SH, NH2, NO2, CN, CON (R5) 2, NHCOR5, COR5, CO2R5, (C1-C6) alkylsulfanyl, (C1-C6) alkylsulfinyl, (C1-C6) alkylsulfonyl, (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) alkoxy and (C1-C6) haloalkoxy; R3 is selected from the group consisting of phenyl, pyridyl and benzothiophenyl, optionally substituted by one or more substituents selected from the group consisting of halogen atoms, OH, oxo, SH, NH2, NO2, CN, CON (R5) 2, COR5 , CO2R5, (C1-C6) alkylsulfanyl, (C1-C6) alkylsulfinyl, (C1-C6) alkylsulfonyl, (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) alkoxy and (C1-C6) haloalkoxy and aryl (C1-C6) alkoxy; R5 is selected, independently at each occurrence, from the group consisting of H, (C1-C6) alkyl, (C2-C6) alkenyl, (C3-C8) cycloalkyl, heteroaryl, and aryl, optionally substituted by one or more selected substituents from the group consisting of halogen atoms, OH, oxo, SH, NH2, NO2, CN, CONH2, COOH, (C1-C6) alkoxycarbonyl, (C1-C6) alkylsulfanyl, (C1-C6) alkylsulfinyl, (C1-C6 ) alkylsulfonyl, (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) alkoxy and (C1-C6) haloalkoxy; Q represents a group of the formula (i) or (ii) ** Formula ** where R4 is a group of the formula (Y) --- (CH2) p --- P --- (CH2q --- W (Y) where p is 0 or an integer from 1 to 4; q is 0 or an integer from 1 to 4; P is absent or selected from the group consisting of O, S, SO, SO2, CO, NR5 CH> = CH, N (R5) SO2, N (R5) COO, N (R5) C (O), SO2N (R5), CO (O) N (R5) and C (O) N (R5); W is selected from the group consisting of H, (C1-C6) alkyl, (C2-C6) alkenyl, (C3-C8) cycloalkyl, aryl, and heteroaryl, optionally substituted by one or more substituents selected from the group consisting of halogen atoms , OH, oxo, SH, NH2, NO2, CN, CON (R5) 2, NHCOR5, COR5, CO2R5, (C1-C6) alkyl, (C1-C6) alkylsulfanyl, (C1-C6) alkylsulfinyl, (C1-C6 ) alkylsulfonyl, (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) alkoxy and (C1-C6) haloalkoxy; A- is a physiologically acceptable anion; and the pharmaceutically acceptable salts thereof; where at minus one between R1 and R3 is a heteroaryl group and, when Q is a group of formula a (i) and R3 is phenyl, R1 is other than 2- (methoxycarbonyl) thioen-3-yl.
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