Abstract 17501: Coronary Artery Disease in Women is Predicted by a Combined Assessment of Carotid and Femoral Plaque Burden

Introduction: Cardiovascular risk remains difficult to assess in women. It is known that femoral plaque development precedes adverse cardiovascular events, such as myocardial infarction. The purpose of this study was to determine the value of a femoral plaque burden assessment, alone or combined with carotid plaque, for identifying significant angiographic coronary artery disease (CAD) in men and women. Methods: Patients referred for coronary angiography underwent same-day carotid and femoral ultrasound. The extent of coronary artery luminal narrowing was established by a 4-segment model to produce an overall angiographic score. Logistic regression models were used to determine the association of carotid and femoral total plaque area (TPA) with significant CAD (≥50% stenosis) when adjusted for age, sex, and risk factors. Optimal cut-off values of plaque burden were determined using areas under receiver operating characteristic curves (AUC). Results: After adjustment, increased femoral, carotid, and combin...