Sarpogrelate combined with Clopidogrel in patients after carotid endarterectomy

Objective To observe the effectiveness and safety of Sarpogrelate as antiplatelet therapy in carotid endarterectomy (CEA) cases.Methods We retrospectively analyzed the clinical data of 64 CEA cases collected from October 2008 to February 2011 at Xuanwu Hospital.According to postoperative antiplatelet medication patients were divided into aspirin combined Clopidogrel group (group A,aspirin 100 mg/d; Clopidogrel 50 mg/d) and Sarpogrelate combined Clopidogrel group (group B,Sarpogrelate 100 mg,tid; Clopidogrel 50 mg/d).Postoperative new stroke,restenosis,bleeding and mortality were compared between groups.Results There were 34 cases in group A and 30 cases in group B.New stroke (one case) (in group B),ipsilateral carotid restenosis (moderate:1 case in group A,2 cases in group B;severe:1 case in group A),bleeding episode (general bleeding event:3 cases in group A including hypodermic gore in 2 cases,gross hematuria in 1 case).There was no death.There was no significant differences between two groups in new stroke,bleeding and restenosis.Conclusions Sarpogrelate combined with Clopidogrel for antiplatelet therapy after CEA was safe and effective. Key words: Endarterectomy, carotid ;  Anticoagulants ;  Clopidogrel;  Sarpogrelate