Acquiring and Exploiting Persistency of Propargyl Radicals: Novel Paradigms
2016
Three complementary methods for altering an intrinsic nature of propargyl radicals, from transient to persistent, were developed by fine-tuning the bulkiness and degree of substitution around the secondary and tertiary propargylic carbons, as well as by sterically enhancing a π-bonded Co2(CO)6 metal core. The latter was employed, as a mechanistic tool, for precluding an acetylene–allene rearrangement, stabilizing propargyl cations, and creating a steric hindrance that could provide for said transition from transient to persistent propargyl radicals. A window of opportunities was identified wherein the steric bulkiness in propargyl radicals remains below the “persistency threshold”, providing good to excellent stereoselectivities in radical dimerization reactions (d,l 62–100%). Along with the persistency threshold for tertiary propargyl radicals (278.2 A3), two different thresholds for persistency in secondary propargyl radicals were established—306.5 and 576.0 A3—dependent upon the molecular architecture ...
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
104
References
3
Citations
NaN
KQI