РОЛЬ ПОЛИМОРФИЗМОВ ГЕНА СRP В ВОЗНИКНОВЕНИИ ФИБРИЛЛЯЦИИ ПРЕДСЕРДИЙ У ПАЦИЕНТОВ ИБС

The purpose . Assessment of the contribution of CRP gene polymorphisms rs3093077, rs1130864 and rs1205 to the development of atrial fibrillation (AF) in CAD patients depending on gender and age. Material and methods. The study included 302 patients with stable coronary artery disease. C-reactive protein (CRP) concentration was measured by high-sensitive immunoturbidimetric assay. The genotyping was performed in 96-well plates using TaqMan assay. Results . The elderly age > 65 years and the presence of type 2 diabetes mellitus are the clinical and anamnestic predictors of AF development (р=0.003; 0.01). G/A rs1130864 CRP heterozygous carriers have a 4-fold increased risk of AF development among the patients with coronary artery disease (p=0.0025) according to the overdominant inheritance model. Men who are the carriers of С/Т rs1205 CRP genotype have on average a 5-fold increased risk of AF development in case of CAD presence (according to the overdominant model, р=0.022). A 5-fold increased risk of AF development is associated with men carrying G/A rs1130864 CRP genotype (p=0.015), meanwhile the men < 65 years, who carry the same genotype (rs1130864 CRP), have a 9-fold increased risk of AF development (p=0.025), as compared to the patients who are the carriers of other genotypes.The patients of both genders < 65 years, carrying the С/Т rs1205 CRP genotype, have a 10-fold increased risk of AF development as compared to the carriers of other genotypes (OR =10.03 (1.26-79.59); 95% CI). Conclusion . The genetic markers should be considered to assess the risk of AF development.