Association of GCK -30G>A Polymorphism with Gestational Diabetes Mellitus and Type 2 Diabetes Mellitus Risk: A Meta-Analysis Involving 18 Case–Control Studies

Objective: Several studies have examined the association between the GCK -30G>A polymorphism and the risk of gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM). However, inferences from these studies are hindered by their limited statistical power and conflicting results. The aim of this meta-analysis is to provide a relatively comprehensive picture of the association of the GCK -30G>A polymorphism with GDM and T2DM risk. Methods: A literature search for eligible studies published before August 15, 2013, was conducted in PubMed, Embase, Web of Science, Cochrane Library, and CNKI (China National Knowledge Infrastructure). Pooled odds ratios with their corresponding 95% confidence intervals were used to evaluate the strength of the association under a fixed- or random-effect model according to heterogeneity test results. All analyses were performed using Stata software, version 12.0. Results: Eighteen case–control studies from 17 published reports were included in this meta-analysis wit...