A Multicenter Comparison of One-Dose Tioconazole Ointment With Three-Dose Terconazole Cream in Vulvovaginal Candidiasis

ABSTRACT A total of 273 patients with proven vulvovaginal candidiasis were enrolled and randomized to treatment with either a single dose of tioconazole 6.5% vaginal ointment or a 3-day course of terconazole 0.8% vaginal cream. The objectives of this multicenter trial were to compare the safety, effectiveness (mycological and clinical cures), and patient acceptance of the two products. A single bedtime dose of tioconazole or three nightly doses of terconazole yielded a negative Nickerson culture and clinical cure that was evident in at least 88% of the evaluable patients from both treatment groups 1 month after drug treatment. Qualitatively and quantitatively, the adverse experiences reported in association with the two drugs were comparable. Patient acceptance was favorable for both drugs in that the applicators for administration were comfortable, easy to use, and the therapy effective. However, there were significant differences (p ≤.05) on other aspects favoring tioconazole over terconazole. A signifi...