DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY EXTRACTION CAPACITY OF MONO- AND BIPHASIC SOLVENT SYSTEMS FOR ISOLATING FLAVONOIDS FROM TRIFOLIUM PRATENSE HERBS

We have studied the extraction of Trifolium pratense L. herbs using aqueous ethanol solutions of various concentration and biphasic systems containing volatile solvents. Dependences of the yield of the active substances on the extractant composition and process factors have been studied. It is established that the maximum total yield of biologically active substances from Trifolium pratense herbs is obtained with the use of biphasic solvent systems.