Effects of asimilobine on dopamine biosynthesis and l-DOPA-induced cytotoxicity in PC12 cells

Chun Mei Jin,Jae-Joon Lee,Young-Kyoon Kim,Shi Yong Ryu,Sung Cil Lim,Bang Yeon Hwang,Chong Kil Lee,Myung Koo Lee

Effects of asimilobine on dopamine biosynthesis and l-DOPA-induced cytotoxicity in PC12 cells

2008

Chun Mei Jin
Jae-Joon Lee
Young-Kyoon Kim
Shi Yong Ryu
Sung Cil Lim
Bang Yeon Hwang
Chong Kil Lee
Myung Koo Lee

Two new ceramides 1 and 2, and tetillapyrone 3 have been isolated from the Indian sponge Cinachyra cavernosa. The structures of 1, 2, and 3 were determined by spectroscopic and chemical analyses.

Keywords:

Chemistry
Alkaloid
Biochemistry
Tyrosine hydroxylase
Biosynthesis
Dopamine
Ceramide
Mechanism of action
Biological activity
Cytotoxicity
Viability assay
Catecholamine
Aromatic L-amino acid decarboxylase
Enzyme inhibitor
Intracellular

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