Веноокклюзионная болезнь печени при трансплантации гемопоэтических стволовых клеток и высокодозных режимах химиотерапии. Обзор литературы

Veno-occlusive liver disease (VOD), now more often referred to as “sinusoidal obstruction syndrome” (SOS), is a symptom complex that develops in the early stages after hematopoietic stem cell transplantation and some chemotherapy regimens due to the toxicity of a number of drugs used and accompanied by the following symptoms: hyperbilirubinemia, fluid retention, weight gain, and painful hepatomegaly. According to various sources, the incidence of SOS/VOD in patients with oncohematological profile ranges from 3 to 15 %. At present, the standard schemes for the prevention of this condition are not fully recommended. The article presents a brief review of the literature, representing international experience in the study and treatment of SOS/VOD.