EFFECT OF CHANNA MICROPELTES IN THE GRANULATION, FIBROSIS AND NECROSIS OF DIABETIC WOUND HEALING

Background: Diabetes mellitus (DM) is characterized by persistent hyperglycemia . T he symptoms of DM is delayed wound healing . Delayed wound healing in diabetes will increase the risk of wound complications that will hinder the healing process, and lead to complications such as fibrosis and necrosis . The use of Channa Micropeltes ( CM ) extract at a dose of 16 mL/kg BW orally is proven to general optimal wound closure and wound contraction clinically in Wistar rats as diabetic model on day 14 . However, the histopathological description of wound healing is yet to be known. Objective : T o analyze the effect of 16 mL/kg BW dose of C M extract on histopathological changes of wound healing granulation tissue, fibrosis and necrosis in diabetic Wistar rats on day 14. M aterials and M ethods : This study was a true experimental design with a post-test only control group design. The samples were divided into two groups, namely the diabetic model group given C M extract at 16 mL/kg BW dose for 14 days, and the diabetic model group given BR2 feed only for 14 days. Results : The results of Mann-Whitney U test showed p = 0.003 for granulation tissue, p = 0.411 for fibrosis and p = 1 for necrosis, with the level of significance was p<0.05. Conclusion : The CM extract at 16 mL/kg BW dose affects the histopathological description of granulation tissue which presents a better result than those in the control group but did not affect the features of fibrosis and necrosis in diabetic Wistar rats on day 14. Keywords : Channa Micropeltes, Diabetic wound, Fibrosis, Granulation tissue, Necrosis.