Preparation method for abiraterone acetate

2012 
A disclosed preparation method for abiraterone acetate comprises the following steps: under the catalysis of a palladium, nickel, copper or iron based catalyst, in an ester organic solvent, performing a coupling reaction on 3beta-acetoxyandrosta-5,16-dien-17- trifluoromethanesulfonate (III) and a compound (VIII) to obtain abiraterone acetate (I). The synthetic route is shown in the specification, and M in the synthetic route is zinc, magnesium or indium. The method provided by the invention is simple, easy for operation, low in cost, relatively high in yield and suitable for industrialized production.
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