Pure red cell aplasia: successful treatment with cyclophosphamide.

Pure red cell aplasia (PRCA) characterized by complete and selective absence of erythroid precursors was observed in a 60 year old female and unsuccessfully treated with corticosteroids and androgens during 21 months. Cyclophosphamide, in contrast, lead to complete and lasting recovery within 6 weeks. Discussing the immunopathological basis of PRCA the significance of specific anti-erythroblast nuclei antibodies is stressed.