Vaginal administration of propranolol to rats: Absorption and histological effects on the vaginal epithelium

Abstract Propranolol solution administered vaginally to ovariectomised rats was absorbed rapidly with peak plasma levels attained 2 min after administration. In addition, the acute effects of propranolol and buffer solutions on the morphology of the vaginal epithelium were quantitated. The thickness of the vaginal epithelium was reduced by each treatment and propranolol solution caused significantly more damage than buffer alone.