Synthesis of Imides via Palladium-Catalyzed Decarboxylative Amidation of α-Oxocarboxylic Acids with Secondary Amides.

An efficient synthesis of imides has been developed through a Pd-catalyzed decarboxylative amidation of α-oxocarboxylic acids with secondary amides. The reactions of N-substituted N-heteroarene-2-carboxamides with 2-oxo-2-arylacetic acids proceeded smoothly to generate the corresponding products in good yields in the presence of Pd(OAc)2 and K2S2O8.