Separate and Combined Effects of Local and Continuous Intravenous Administration of β-Cyclodextrin Tetradecasulfate on Intimal Hyperplasia after Angioplasty in Porcine Coronary Arteries

Background: Beta-Cyclodextrin tetradecasulfate binds fibroblast growth factors and possesses anticoagulant properties. This study was designed to assess the separate and combined effects of local intramural delivery and intravenous administration of β-cyclodextrin tetradecasulfate on neointimal formation and arterial damage following angioplasty.Methods and Results: Fifty-two pigs randomized into four groups underwent coronary artery angioplasty: 1) control, 2) continuous intravenous infusion of 100 mg/kg/d of β-cyclodextrin tetradecasulfate, 3) intramural delivery of 1250 mg β-cyclodextrin tetradecasulfate, 4) intramural delivery of 1250 mg β-cyclodextrin tetradecasulfate followed by continuous intravenous infusion of 100 mg/kg/d. Fourteen days after injury, morphometric analysis revealed that arteries randomized to the intravenous β-cyclodextrin tetradecasulfate groups had a decreased normalized neointima area: control, 3.03 ± 0.75 mm2; intravenous, 1.67 ± 0.73 mm2 (40% decrease; P < 10-7); intravenous ...