The impact of synovial macrophage polarisation state on chondrogenic differentiation of mesenchymal stem cells

s / Osteoarthritis and Cartilage 22 (2014) S7–S56 S22 Conclusions: Our findings demonstrate that a significant and likely clinically important predictive association exists between worsened scores on psychosocial measures (negative mood and the use of passive coping strategies) and OA pain flares. Further work to better elucidate this connection will be important, as psychosocial factors such as mood and pain coping are modifiable and may represent an important target for efforts designed to prevent and treat OA pain flares. Fig. 1. MI macrophage conditioned medium (CM) inhibits chondrogenic gene expression by MSCs. *1⁄4p<0.005, **1⁄4p<0.001. Table Association of psychosocial factors with pain exacerbation