Esomeprazole vs. Omeprazole for Reflux Esophagitis

Esomeprazole is the S-isomer of omeprazole. Results of pharmacokinetic and pharmacodynamic studies have demonstrated higher systemic bioavailability for esomeprazole compared with omeprazole because of less first-pass hepatic metabolism and lower plasma clearance. Researchers conducted this double-blind, multicenter study to examine the potential clinical implications of esomeprazole in the treatment of patients with gastroesophageal reflux disease (GERD). They …