Serum creatinine level in predicting the development of hypertension. Ten-year follow-up of Japanese adults in a rural community.

In a 10-year prospective study, we investigated the utility of the serum creatinine level in predicting the development of hypertension in japanese adults, all of whom lived in a rural community. The study included 229 subjects, 91 men and 138 women aged 30 to 69 years, who were normotensive (systolic blood pressure 140 mm Hg or less and diastolic blood pressure 90 mm Hg or less) and had no prior history of antihypertensive treatment at baseline (1979 to 1980). Hypertension was defined as systolic blood pressure more than 140 mm Hg and diastolic blood pressure more than 90 mm Hg and starting antihypertensive medication