Organocatalytic Enantioselective Synthesis of 1‐Vinyl Tetrahydroisoquinolines Through Allenamide Activation with Chiral Broensted Acids.

Elisabetta Manoni,Andrea Gualandi,Luca Mengozzi,Marco Bandini,Pier Giorgio Cozzi

Organocatalytic Enantioselective Synthesis of 1‐Vinyl Tetrahydroisoquinolines Through Allenamide Activation with Chiral Broensted Acids.

2015

Elisabetta Manoni
Andrea Gualandi
Luca Mengozzi
Marco Bandini
Pier Giorgio Cozzi

1-Vinyl tetrahydroisoquinoline ((R)-II) is synthesized through a metal-free strategy for a stereoselective Friedel—Crafts-type cyclization reaction using an axial-chiral phosphoric acid as catalyst.

Keywords:

Tetrahydroisoquinoline
Phosphoric acid
Catalysis
Enantioselective synthesis
Chirality (chemistry)
Organic chemistry
Stereoselectivity
Chemistry

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