SELECTIVE N-FUNCTIONALIZATION OF 6-SUBSTITUTED-2-PYRIDONES

Summary 6-Substituted-2-pyridones can be selectively N -alkylated by treatment with NaH/LiBr in a mixture of DMF and DME. Yields of N -propargylated, N -allylated, and other N -functionalized products are good, and only small amounts of the isomeric O -alkylated product (