Catechu Inhibiting Cathepsin B Activity and Motility of HT1080 Cells

We reported that Catechu extract has a significant inhibitory effect on cathepsin B activity. The IC50 value for the Catechu extract against cathepsin B was 7.6 µg/mL. In addition, we showed that HT1080 human fibrosarcoma cells express cathepsin B and Catechu modulate the invasion and motility of these cells. These data may provide mo- lecular mechanisms for the therapeutic effects of Catechu. Keywords Cathepsin B; Traditional Chinese medicine; Catechu; Tumor; Cell invasion; Cell motility Article ID 1005-9040(2011)-02-269-04