Neonatal Exposure to 6-n-Propyl-Thiouracil, an Anti-Thyroid Drug, Alters Expression of Hepatic DNA Methyltransferases, Methyl CpG-Binding Proteins, Gadd45a, p53, and PCNA in Adult Male Rats

Suresh Kumar Bunker,Jagneshwar Dandapat,G.B.N. Chainy,Sunil Kumar Sahoo,Prabhat Kumar Nayak

Neonatal Exposure to 6-n-Propyl-Thiouracil, an Anti-Thyroid Drug, Alters Expression of Hepatic DNA Methyltransferases, Methyl CpG-Binding Proteins, Gadd45a, p53, and PCNA in Adult Male Rats

2017

Suresh Kumar Bunker
Jagneshwar Dandapat
G.B.N. Chainy
Sunil Kumar Sahoo
Prabhat Kumar Nayak

Background: Neonatal 6-n-propyl-2-thiouracil (PTU) exposure to male rats is reported to impair liver function in adulthood. However, the mechanism by which the dr

Keywords:

Thiouracil
Proliferating cell nuclear antigen
Methyl-CpG binding
DNA
GADD45A
Thyroid drug
Methyltransferase
Biology
Molecular biology
Internal medicine
Downregulation and upregulation
DNA methylation
MBD4
DNA damage
Endocrinology
liver function

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